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Tuesday, October 6, 2026 Week 5 · Early Edition

NFL · 2026 season · 3–1 against the closing spread

San Francisco 49ers

Next: 49ers at Seahawks, Sun Oct 11, 4:25 PM ET. 49ers +3, opened +3.5, total 46.5.

49ers Injury Report · Week 5

PlayerPosStatus this weekWorth (pts)Updated
Nick BosaEDGEOut → Doubtful -0.0Tue Oct 6, 2:54 PM
Marques SigleSActive → Questionable → Doubtful 0.0Mon Oct 5, 5:51 PM

Starters only, as reported by the team and ESPN. Worth = his value over his healthy backup, in points against the 49ers. Questionable starters have sat 36% of the time this season.

Latest 49ers News

FinalSun Oct 4, 7:37 PM

49ers Beat Broncos 24–14

Final: Denver Broncos 14, San Francisco 49ers 24. The closing line was 49ers −3; San Francisco covered by 7. The 38 combined points went under the closing total of 48.5.

InjurySun Oct 4, 7:24 PM

49ers fullback Juszczyk knocked out with knee injury vs Denver

San Francisco fullback Kyle Juszczyk suffered a knee injury and will not return against the Broncos. The 49ers led 17-14 at the time and lose a key piece of their run and short-yardage packages, with his status for next week unclear. ProFootballTalk

RosterSat Oct 3, 5:03 PM

Judon elevated, set for 49ers debut vs Broncos

San Francisco elevated veteran defensive end Matt Judon from the practice squad for Sunday's game against Denver. It would be his first appearance with the 49ers and adds a pass rusher to the rotation. ProFootballTalk

RosterSat Oct 3, 4:43 PM

49ers shuffle defensive line before Denver game

San Francisco promoted defensive lineman Sebastian Valdez to the active roster, elevated two practice squad players and waived Viliami Fehoko Jr. The moves adjust the 49ers' defensive line depth for Sunday's game against Denver. San Francisco 49ers (team site)

WeatherFri Oct 2, 8:36 PM

Heat at Kickoff for Broncos at 49ers

The forecast for kickoff at Levi's Stadium calls for 91°F. Forecasts change; this note updates as the game gets closer.

InjuryFri Oct 2, 6:15 PM

Evans a game-day call for 49ers against Broncos

San Francisco receiver Mike Evans is questionable with a rib injury and his status will be decided close to kickoff Sunday. He indicated he intends to try to play against Denver. ESPN

FinalTue Sep 29, 2:57 PM

49ers Beat Dolphins 35–13

Final: Miami Dolphins 13, San Francisco 49ers 35. The closing line was 49ers −13; San Francisco covered by 9.

FinalTue Sep 29, 2:57 PM

49ers Beat Rams 27–7

Final: San Francisco 49ers 27, Los Angeles Rams 7. San Francisco won outright as the underdog; the closing line was Rams −3.5.

FinalTue Sep 29, 1:16 AM

49ers Beat Cardinals 36–30

Final: Arizona Cardinals 30, San Francisco 49ers 36. The closing line was 49ers −7.5; Arizona covered by 1.5. The market moved San Francisco 1 points over Nick Bosa's absence (−8.5 to −7.5); 49ers fell short of it by 1.5.

InjuryMon Sep 28, 10:57 PM

49ers expect short absences for Evans, Williams and Greenlaw

Kyle Shanahan said the injuries suffered Sunday by Mike Evans, Trent Williams and Dre Greenlaw are not viewed as long-term problems. That keeps three key contributors in play for the Week 4 matchup with Denver rather than ruling them out for an extended stretch. ESPN

2026 Season: How the Line Moved

WeekGameOpenedClosedMoveResultSpread
1at Rams +3.5+3.5 — W 27–7Covered
2vs. Dolphins −13−13 — W 35–13Covered
3vs. Cardinals −8.5−7.5 +1.0 W 36–30Didn't cover
4vs. Broncos −3.5−3 +0.5 W 24–14Covered
5at Seahawks +3.5+3 −0.5 Upcoming—
6vs. Commanders −7.5−7.5 — Upcoming—

The 49ers' consensus spread (median of U.S. sportsbooks and Kalshi) at our first look and at kickoff. A positive move means the market moved against the 49ers.

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